Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons

The disease mechanism of Rett syndrome (RTT) is not well understood. Studies in RTT mouse models have suggested a non-cell-autonomous role for astrocytes in RTT pathogenesis. However, it is not clear whether this is also true for human RTT astrocytes. To establish an in vitro human RTT model, we pre...

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Detalhes bibliográficos
Main Authors: Williams, Emily Cunningham, Zhong, Xiaofen, Mohamed, Ahmed, Li, Ronghui, Liu, Yan, Dong, Qiping, Ananiev, Gene E., Mok, Jonathan Chern Choong, Lin, Benjamin Ray, Lu, Jianfeng, Chiao, Cassandra, Cherney, Rachel, Li, Hongda, Zhang, Su-Chun, Chang, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014193/
https://ncbi.nlm.nih.gov/pubmed/24419315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu008
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