Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons

The disease mechanism of Rett syndrome (RTT) is not well understood. Studies in RTT mouse models have suggested a non-cell-autonomous role for astrocytes in RTT pathogenesis. However, it is not clear whether this is also true for human RTT astrocytes. To establish an in vitro human RTT model, we pre...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Williams, Emily Cunningham, Zhong, Xiaofen, Mohamed, Ahmed, Li, Ronghui, Liu, Yan, Dong, Qiping, Ananiev, Gene E., Mok, Jonathan Chern Choong, Lin, Benjamin Ray, Lu, Jianfeng, Chiao, Cassandra, Cherney, Rachel, Li, Hongda, Zhang, Su-Chun, Chang, Qiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
Soggetti:
Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014193/
https://ncbi.nlm.nih.gov/pubmed/24419315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu008
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi