Reprogramming tumor-infiltrating dendritic cells for CD103(+)CD8(+) mucosal T cell differentiation and breast cancer rejection

Our studies showed that tumor-infiltrating dendritic cells (DC) in breast cancer drive inflammatory T helper 2 (iTh2) cells and protumor inflammation. Here we show that intratumoral delivery of the β-glucan curdlan, a ligand of dectin-1, blocks the generation of iTh2 cells, and prevents breast cance...

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Main Authors: Wu, Te-Chia, Xu, Kangling, Banchereau, Romain, Marches, Florentina, Yu, Chun I, Martinek, Jan, Anguiano, Esperanza, Pedroza-Gonzalez, Alexander, Snipes, G. Jackson, O’Shaughnessy, Joyce, Nishimura, Stephen, Liu, Yong-Jun, Pascual, Virginia, Banchereau, Jacques, Oh, Sangkon, Palucka, Karolina
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014008/
https://ncbi.nlm.nih.gov/pubmed/24795361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-13-0217
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