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Poly(ADP-ribose) polymerase-1 and its cleavage products differentially modulate cellular protection through NF-kB-dependent signaling
Poly(ADP-ribose) polymerase-1 (PARP-1) and its cleavage products regulate cell viability and NF-kB activity when expressed in neurons. PARP-1 cleavage generates a 24kDa (PARP-1(24)) and an 89kDa fragment (PARP-1(89)). Compared to WT (PARP-1(WT)), the expression of an uncleavable PARP-1 (PARP-1(UNCL)...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4013233/ https://ncbi.nlm.nih.gov/pubmed/24333653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2013.12.005 |
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