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Development of a Transgenic Plasmodium berghei Line (Pb(pfpkg)) Expressing the P. falciparum cGMP-Dependent Protein Kinase, a Novel Antimalarial Drug Target

With the inevitable selection of resistance to antimalarial drugs in treated populations, there is a need for new medicines to enter the clinic and new targets to progress through the drug discovery pipeline. In this study we set out to develop a transgenic rodent model for testing inhibitors of the...

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Main Authors: Tewari, Rita, Patzewitz, Eva-Maria, Poulin, Benoit, Stewart, Lindsay, Baker, David A.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013051/
https://ncbi.nlm.nih.gov/pubmed/24805991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096923
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