Directing Group-Controlled Regioselectivity in an Enzymatic C–H Bond Oxygenation

[Image: see text] Highly regioselective remote hydroxylation of a natural product scaffold is demonstrated by exploiting the anchoring mechanism of the biosynthetic P450 monooxygenase PikC(D50N)-RhFRED. Previous studies have revealed structural and biochemical evidence for the role of a salt bridge...

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Detalhes bibliográficos
Main Authors: Negretti, Solymar, Narayan, Alison R. H., Chiou, Karoline C., Kells, Petrea M., Stachowski, Jessica L., Hansen, Douglas A., Podust, Larissa M., Montgomery, John, Sherman, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012894/
https://ncbi.nlm.nih.gov/pubmed/24627965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5016052
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