Enzymatic Hydroxylation of an Unactivated Methylene C–H Bond Guided by Molecular Dynamics Simulations

The hallmark of enzymes from secondary metabolic pathways is the pairing of powerful reactivity with exquisite site selectivity. The application of these biocatalytic tools in organic synthesis, however, remains under-utilized due to limitations in substrate scope and scalability. Here we report the...

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Detalhes bibliográficos
Publicado no:Nat Chem
Main Authors: Narayan, Alison R. H., Jiménez-Osés, Gonzalo, Liu, Peng, Negretti, Solymar, Zhao, Wanxiang, Gilbert, Michael M., Ramabhadran, Raghunath O., Yang, Yun-Fang, Furan, Lawrence R., Li, Zhe, Podust, Larissa M., Montgomery, John, Houk, K. N., Sherman, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518477/
https://ncbi.nlm.nih.gov/pubmed/26201742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2285
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