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Comparative functional analysis of DPYD variants of potential clinical relevance to dihydropyrimidine dehydrogenase activity
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate limiting enzyme of the uracil catabolic pathway, being critically important for inactivation of the commonly prescribed anti-cancer drug 5-fluorouracil (5-FU). DPD impairment leads to increased exposure to 5-FU and, in turn, increased ana...
Gorde:
| Egile Nagusiak: | , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2014
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4012613/ https://ncbi.nlm.nih.gov/pubmed/24648345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2482 |
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