Intermittent chemotherapy plus either intermittent or continuous cetuximab for first-line treatment of patients with KRAS wild-type advanced colorectal cancer (COIN-B): a randomised phase 2 trial

BACKGROUND: Advanced colorectal cancer is treated with a combination of cytotoxic drugs and targeted treatments. However, how best to minimise the time spent taking cytotoxic drugs and whether molecular selection can refine this further is unknown. The primary aim of this study was to establish how...

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Detalhes bibliográficos
Main Authors: Wasan, Harpreet, Meade, Angela M, Adams, Richard, Wilson, Richard, Pugh, Cheryl, Fisher, David, Sydes, Benjamin, Madi, Ayman, Sizer, Bruce, Lowdell, Charles, Middleton, Gary, Butler, Rachel, Kaplan, Richard, Maughan, Tim
Formato: Artigo
Idioma:Inglês
Publicado em: Lancet Pub. Group 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012566/
https://ncbi.nlm.nih.gov/pubmed/24703531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(14)70106-8
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