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Combination of the ABL kinase inhibitor imatinib with the Janus kinase 2 inhibitor TG101348 for targeting residual BCR-ABL-positive cells

BACKGROUND: The ABL kinase inhibitor imatinib is highly effective in treating most, but not all, patients with chronic myeloid leukemia (CML). This is because residual CML cells are generally present in the bone marrow microenvironment and are refractory to imatinib. Hematopoietic cytokine receptor...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Okabe, Seiichi, Tauchi, Tetsuzo, Katagiri, Seiichiro, Tanaka, Yuko, Ohyashiki, Kazuma
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012544/
https://ncbi.nlm.nih.gov/pubmed/24775308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-7-37
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