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Combination of the ABL kinase inhibitor imatinib with the Janus kinase 2 inhibitor TG101348 for targeting residual BCR-ABL-positive cells

BACKGROUND: The ABL kinase inhibitor imatinib is highly effective in treating most, but not all, patients with chronic myeloid leukemia (CML). This is because residual CML cells are generally present in the bone marrow microenvironment and are refractory to imatinib. Hematopoietic cytokine receptor...

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Bibliografische gegevens
Hoofdauteurs: Okabe, Seiichi, Tauchi, Tetsuzo, Katagiri, Seiichiro, Tanaka, Yuko, Ohyashiki, Kazuma
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012544/
https://ncbi.nlm.nih.gov/pubmed/24775308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-7-37
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