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Combining the ABL1 kinase inhibitor ponatinib and the histone deacetylase inhibitor vorinostat: a potential treatment for BCR-ABL-positive leukemia.

Resistance to imatinib (Gleevec®) in cancer cells is frequently because of acquired point mutations in the kinase domain of BCR-ABL. Ponatinib, also known as AP24534, is an oral multi-targeted tyrosine kinase inhibitor (TKI), and it has been investigated in a pivotal phase 2 clinical trial. The hist...

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Autori principali: Seiichi Okabe, Tetsuzo Tauchi, Shinya Kimura, Taira Maekawa, Toshihiko Kitahara, Yoko Tanaka, Kazuma Ohyashiki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2014-01-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC3938434?pdf=render
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