Possible impact of the CYP2D6*10 polymorphism on the nonlinear pharmacokinetic parameter estimates of paroxetine in Japanese patients with major depressive disorders

It has been suggested that the reduced function allele with reduced cytochrome P450 (CYP) 2D6 activity, CYP2D6*10, is associated with the interindividual differences in the plasma paroxetine concentrations, but there is no data presently available regarding the influence of the CYP2D6*10 polymorphis...

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Главные авторы: Saruwatari, Junji, Nakashima, Hiroo, Tsuchimine, Shoko, Nishimura, Miki, Ogusu, Naoki, Yasui-Furukori, Norio
Формат: Artigo
Язык:Inglês
Опубликовано: Dove Medical Press 2014
Предметы:
Rapid Communication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012347/
https://ncbi.nlm.nih.gov/pubmed/24868171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S60747
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