A Vaccine of L2 Epitope Repeats Fused with a Modified IgG1 Fc Induced Cross-Neutralizing Antibodies and Protective Immunity against Divergent Human Papillomavirus Types

Current human papillomavirus (HPV) major capsid protein L1 virus-like particles (VLPs)-based vaccines in clinic induce strong HPV type-specific neutralizing antibody responses. To develop pan-HPV vaccines, here, we show that the fusion protein E3R4 consisting of three repeats of HPV16 L2 aa 17–36 ep...

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Detalhes bibliográficos
Main Authors: Chen, Xue, Liu, Hongyang, Zhang, Ting, Liu, Yanchun, Xie, Xixiu, Wang, Zhirong, Xu, Xuemei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011685/
https://ncbi.nlm.nih.gov/pubmed/24802101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095448
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