miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1

The serine threonine kinase Akt1 has been implicated in the control of cellular metabolism, survival and growth. Herein, disruption of the ubiquitously expressed member of the Akt family of genes, Akt1, in the mouse, demonstrates a requirement for Akt1 in miRNA-mediated cellular apoptosis. The miR-1...

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Bibliographische Detailangaben
Hauptverfasser: Yu, Zuoren, Xu, Zengguang, DiSante, Gabriele, Wright, Jennifer, Wang, Min, Li, Yuan, Zhao, Qian, Ren, Tao, Ju, Xiaoming, Gutman, Ellen, Wang, Guangxue, Addya, Sankar, Li, Tieyan, Xiang, Zhendong, Wang, Chenguang, yang, Xiongfei, Yang, Xiaolai, Pestell, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011585/
https://ncbi.nlm.nih.gov/pubmed/24658544
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