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Development of (Trimethylsilyl)ethyl Ester Protected Enolates and Applications in Palladium-Catalyzed Enantioselective Allylic Alkylation: Intermolecular Cross-Coupling of Functionalized Electrophiles

[Image: see text] The development of (trimethylsilyl)ethyl ester protected enolates is reported. The application of this class of compounds in palladium-catalyzed asymmetric allylic alkylation is explored, yielding a variety of α-quaternary six- and seven-membered ketones and lactams. Independent co...

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Autores principales: Reeves, Corey M., Behenna, Douglas C., Stoltz, Brian M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2014
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011571/
https://ncbi.nlm.nih.gov/pubmed/24724872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol500355z
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