Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis.

The retinoblastoma protein (RB) has been proposed to function as a negative regulator of cell proliferation by complexing with cellular proteins such as the transcription factor E2F. To study the biological consequences of the RB/E2F-1 interaction, point mutants of E2F-1 which fail to bind to RB wer...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Shan, B, Durfee, T, Lee, W H
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40112/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8570615/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.2.679
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