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The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses
The C1858T single nucleotide polymorphism in PTPN22, which is the gene encoding lymphoid tyrosine phosphatase (LYP), confers increased risk for various autoimmune disorders in Caucasians. Although the disease-associated LYP allele (LYP*W620) is a gain-of-function variant that has higher catalytic ac...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4011173/ https://ncbi.nlm.nih.gov/pubmed/23333624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humimm.2012.12.017 |
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