The mineralocorticoid receptor-p38MAPK-NFκB or ERK-Sp1 signal pathways mediate aldosterone-stimulated inflammatory and profibrotic responses in rat vascular smooth muscle cells

AIM: To explore the signalling pathways involved in aldosterone-induced inflammation and fibrosis in rat vascular smooth muscle cells (VSMCs). METHODS: Using Western blotting and real-time RT-PCR, we investigated the effects of aldosterone on the expression of cyclooxygenase-2 (Cox-2) and IL-6, two...

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Detalhes bibliográficos
Main Authors: Zhu, Chuan-jiang, Wang, Qing-qing, Zhou, Jun-lan, Liu, Han-zhi, Hua, Fang, Yang, Hong-zheng, Hu, Zhuo-wei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011158/
https://ncbi.nlm.nih.gov/pubmed/22659623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.36
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