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Intracellular Hydrogen Peroxide and Superoxide Poison 3-Deoxy-d-Arabinoheptulosonate 7-Phosphate Synthase, the First Committed Enzyme in the Aromatic Biosynthetic Pathway of Escherichia coli

In Escherichia coli, aromatic compound biosynthesis is the process that has shown the greatest sensitivity to hydrogen peroxide stress. This pathway has long been recognized to be sensitive to superoxide as well, but the molecular target was unknown. Feeding experiments indicated that the bottleneck...

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Podrobná bibliografie
Hlavní autoři: Sobota, Jason M., Gu, Mianzhi, Imlay, James A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010980/
https://ncbi.nlm.nih.gov/pubmed/24659765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01573-14
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