Deoxycytidine Deaminase-Deficient Escherichia coli Strains Display Acute Sensitivity to Cytidine, Adenosine, and Guanosine and Increased Sensitivity to a Range of Antibiotics, Including Vancomycin

We show here that deoxycytidine deaminase (DCD)-deficient mutants of Escherichia coli are hypersensitive to killing by exogenous cytidine, adenosine, or guanosine, whereas wild-type cells are not. This hypersensitivity is reversed by exogenous thymidine. The mechanism likely involves the allosteric...

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Detalhes bibliográficos
Main Authors: Kang, Tina Manzhu, Yuan, Jessica, Zhou, Alice, Beppler, Casey, Miller, Jeffrey H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010977/
https://ncbi.nlm.nih.gov/pubmed/24633874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01383-13
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