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Exposure to a histone deacetylase inhibitor has detrimental effects on human lymphocyte viability and function

Histone deacetylase inhibitors (HDACi) have been reported to increase tumor antigen expression, and have been successfully tested as adjuvants for melanoma immunotherapy in mouse models. In this work, we tested the effects of a pan-HDACi on human lymphocytes and melanoma cell lines. Effects of the p...

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Main Authors: Wong, Deborah J.L., Rao, Amol, Avramis, Earl, Matsunaga, Douglas R., Komatsubara, Kimberly M., Atefi, Mohammad S., Escuin-Ordinas, Helena, Chodon, Thinle, Koya, Richard C., Ribas, Antoni, Comin-Anduix, Begoña
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010948/
https://ncbi.nlm.nih.gov/pubmed/24795358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-13-0188
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