Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function

Lrrc8a is a ubiquitously expressed gene that encodes a leucine-rich repeat (LRR)–containing protein detected at higher levels on the surface of thymocytes than on other immune cells. We generated Lrrc8a(−/−) mice to investigate the role of LRRC8A in lymphocyte development and function. Lrrc8a(−/−) m...

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Main Authors: Kumar, Lalit, Chou, Janet, Yee, Christina S.K., Borzutzky, Arturo, Vollmann, Elisabeth H., von Andrian, Ulrich H., Park, Shin-Young, Hollander, Georg, Manis, John P., Poliani, P. Luigi, Geha, Raif S.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010910/
https://ncbi.nlm.nih.gov/pubmed/24752297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131379
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