RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance

We report that programmed death ligand 2 (PD-L2), a known ligand of PD-1, also binds to repulsive guidance molecule b (RGMb), which was originally identified in the nervous system as a co-receptor for bone morphogenetic proteins (BMPs). PD-L2 and BMP-2/4 bind to distinct sites on RGMb. Normal restin...

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Detalhes bibliográficos
Main Authors: Xiao, Yanping, Yu, Sanhong, Zhu, Baogong, Bedoret, Denis, Bu, Xia, Francisco, Loise M., Hua, Ping, Duke-Cohan, Jonathan S., Umetsu, Dale T., Sharpe, Arlene H., DeKruyff, Rosemarie H., Freeman, Gordon J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010901/
https://ncbi.nlm.nih.gov/pubmed/24752301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130790
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