PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

Tumor-infiltrating myeloid cells such as myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) form an important component of the hypoxic tumor microenvironment. Here, we investigated the influence of hypoxia on immune checkpoint receptors (programmed death [PD]-1 and CTLA...

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Detalhes bibliográficos
Main Authors: Noman, Muhammad Zaeem, Desantis, Giacomo, Janji, Bassam, Hasmim, Meriem, Karray, Saoussen, Dessen, Philippe, Bronte, Vincenzo, Chouaib, Salem
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010891/
https://ncbi.nlm.nih.gov/pubmed/24778419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131916
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