SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism

Oxidative and carbonyl stress is increased in lungs of smokers and patients with chronic obstructive pulmonary disease (COPD), as well as in cigarette smoke (CS)-exposed rodent lungs. We previously showed that sirtuin1 (SIRT1), an antiaging protein, is reduced in lungs of CS-exposed mice and patient...

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Auteurs principaux: Yao, Hongwei, Sundar, Isaac K., Ahmad, Tanveer, Lerner, Chad, Gerloff, Janice, Friedman, Alan E., Phipps, Richard P., Sime, Patricia J., McBurney, Michael W., Guarente, Leonard, Rahman, Irfan
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2014
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010647/
https://ncbi.nlm.nih.gov/pubmed/24633890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00323.2013
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