HRAS Mutations and Resistance to the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Erlotinib in Head and Neck Squamous Cell Carcinoma Cells

BACKGROUND: This was to identify mechanisms of innate resistance to an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, erlotinib, in a panel of head and neck squamous cell carcinoma (HNSCC) cell lines. Specifically, we analyzed the role of HRAS mutations in erlotinib resistance. M...

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Main Authors: Hah, J. Hun, Zhao, Mei, Pickering, Curtis R., Frederick, Mitchell J., Andrews, Genevieve A., Jasser, Samar A., Fooshee, David R., Milas, Zvonimir L., Galer, Chad, Sano, Daisuke, William, William N., Kim, Edward, Heymach, John, Byers, Lauren A., Papadimitrakopoulou, Vali, Myers, Jeffrey N.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010580/
https://ncbi.nlm.nih.gov/pubmed/24123531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hed.23499
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