Role of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization

Agonist-activated μ-opioid receptor (OPRM1) undergoes robust receptor phosphorylation by G protein-coupled receptor kinases and subsequent β-arrestin recruitment, triggering receptor internalization and desensitization. Morphine, a widely prescribed opioid, induces receptor phosphorylation inefficie...

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Bibliografiske detaljer
Main Authors: Yan, Ying-Hui, Wang, Yan, Zhao, Lan-Xue, Jiang, Shan, Loh, Horace H., Law, Ping-Yee, Chen, Hong-Zhuan, Qiu, Yu
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010564/
https://ncbi.nlm.nih.gov/pubmed/24607931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2014.02.059
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