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A Systems Chemical Biology Study of Malate Synthase and Isocitrate Lyase Inhibition in Mycobacterium tuberculosis During Active and NRP Growth

The ability of Mycobacterium tuberculosis (Mtb) to survive in low oxygen environments enables the bacterium to persist in a latent state within host tissues. In vitro studies of Mtb growth have identified changes in isocitrate lyase (ICL) and malate synthase (MS) that enable bacterial persistent und...

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Bibliografiska uppgifter
Huvudupphovsmän: May, Elebeoba E., Leitão, Andrei, Tropsha, Alexander, Oprea, Tudor I.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010430/
https://ncbi.nlm.nih.gov/pubmed/24121675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.compbiolchem.2013.07.002
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