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Sirt1 overexpression protects murine osteoblasts against TNF-α-induced injury in vitro by suppressing the NF-κB signaling pathway

AIM: Sirtuin 1 (Sirt1) is the class III histone/protein deacetylase that interferes with the NF-κB signaling pathway, thereby has anti-inflammatory function. This study was undertaken to investigate whether Sirt1 could protect osteoblasts against TNF-α-induced injury in vitro. METHODS: Murine osteob...

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Main Authors: Huang, Wei, Shang, Wei-lin, Wang, Hua-dong, Wu, Wen-wen, Hou, Shu-xun
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010359/
https://ncbi.nlm.nih.gov/pubmed/22447223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.189
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