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Robust methods for differential abundance analysis in marker gene surveys
We introduce a novel methodology for differential abundance analysis in sparse high-throughput marker gene survey data. Our approach, implemented in the metagenomeSeq Bioconductor package, relies on a novel normalization technique and a statistical model that accounts for under-sampling: a common fe...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4010126/ https://ncbi.nlm.nih.gov/pubmed/24076764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.2658 |
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