Novel gastroretentive sustained-release tablet of tacrolimus based on self-microemulsifying mixture: in vitro evaluation and in vivo bioavailability test

AIM: To develop a novel gastroretentive drug delivery system based on a self-microemulsifying (SME) lipid mixture for improving the oral absorption of the immunosuppressant tacrolimus. METHODS: Liquid SME mixture, composed of Cremophor RH40 and monocaprylin glycerate, was blended with polyethylene o...

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Main Authors: Wang, Yan-ping, Gan, Yong, Zhang, Xin-xin
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2011
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010087/
https://ncbi.nlm.nih.gov/pubmed/21927013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.90
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