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Novel gastroretentive sustained-release tablet of tacrolimus based on self-microemulsifying mixture: in vitro evaluation and in vivo bioavailability test
AIM: To develop a novel gastroretentive drug delivery system based on a self-microemulsifying (SME) lipid mixture for improving the oral absorption of the immunosuppressant tacrolimus. METHODS: Liquid SME mixture, composed of Cremophor RH40 and monocaprylin glycerate, was blended with polyethylene o...
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| Główni autorzy: | , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Publishing Group
2011
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4010087/ https://ncbi.nlm.nih.gov/pubmed/21927013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.90 |
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