Metabolism of novel anti-HIV agent 3-cyanomethyl-4-methyl-DCK by human liver microsomes and recombinant CYP enzymes

AIM: To investigate the metabolism of 3-cyanomethyl-4-methyl-DCK (CMDCK), a novel anti-HIV agent, by human liver microsomes (HLMs) and recombinant cytochrome P450 enzymes (CYPs). METHODS: CMDCK was incubated with HLMs or a panel of recombinant cytochrome P450 enzymes including CYP1A2, 2B6, 2C8, 2C9,...

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Main Authors: Zhuang, Xiao-mei, Deng, Jing-ting, Li, Hua, Kong, Wei-li, Ruan, Jin-xiu, Xie, Lan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010078/
https://ncbi.nlm.nih.gov/pubmed/21970838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.91
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