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Metabolism of novel anti-HIV agent 3-cyanomethyl-4-methyl-DCK by human liver microsomes and recombinant CYP enzymes
AIM: To investigate the metabolism of 3-cyanomethyl-4-methyl-DCK (CMDCK), a novel anti-HIV agent, by human liver microsomes (HLMs) and recombinant cytochrome P450 enzymes (CYPs). METHODS: CMDCK was incubated with HLMs or a panel of recombinant cytochrome P450 enzymes including CYP1A2, 2B6, 2C8, 2C9,...
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主要な著者: | , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
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Nature Publishing Group
2011
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オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4010078/ https://ncbi.nlm.nih.gov/pubmed/21970838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.91 |
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