CYP2J2 and CYP2C19 Are the Major Enzymes Responsible for Metabolism of Albendazole and Fenbendazole in Human Liver Microsomes and Recombinant P450 Assay Systems

Albendazole and fenbendazole are broad-spectrum anthelmintics that undergo extensive metabolism to form hydroxyl and sulfoxide metabolites. Although CYP3A and flavin-containing monooxygenase have been implicated in sulfoxide metabolite formation, the enzymes responsible for hydroxyl metabolite forma...

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Autori principali: Wu, Zhexue, Lee, Doohyun, Joo, Jeongmin, Shin, Jung-Hoon, Kang, Wonku, Oh, Sangtaek, Lee, Do Yup, Lee, Su-Jun, Yea, Sung Su, Lee, Hye Suk, Lee, Taeho, Liu, Kwang-Hyeon
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811268/
https://ncbi.nlm.nih.gov/pubmed/23959307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00843-13
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