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Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis
The mutation F508del is the commonest cause of the genetic disease cystic fibrosis (CF). CF disrupts the function of many organs in the body, most notably the lungs, by perturbing salt and water transport across epithelial surfaces. F508del causes harm in two principal ways. First, the mutation prev...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4009972/ https://ncbi.nlm.nih.gov/pubmed/21642944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.71 |
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