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The dual PPARα/γ agonist aleglitazar increases the number and function of endothelial progenitor cells: implications for vascular function and atherogenesis

BACKGROUND AND PURPOSE: Aleglitazar is a dual PPARα/γ agonist but little is known about its effects on vascular function and atherogenesis. Hence, we characterized its effects on circulating angiogenic cells (CAC), neoangiogenesis, endothelial function, arteriogenesis and atherosclerosis in mice. EX...

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Autori principali: Werner, C M, Schirmer, S H, Gensch, C, Pavlickova, V, Pöss, J, Wright, M B, Böhm, M, Laufs, U
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4009009/
https://ncbi.nlm.nih.gov/pubmed/24467636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12608
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