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Polycystin-1: a master regulator of intersecting cystic pathways

Autosomal dominant polycystic kidney disease (ADPKD) is the most common potentially lethal monogenic disorder, with more than 12 million cases worldwide. The two causative genes for ADPKD, PKD1 and PKD2, encode protein products polycystin-1 (PC1) and polycystin-2 (PC2 or TRPP2), respectively. Recent...

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Autori principali: Fedeles, Sorin V., Gallagher, Anna-Rachel, Somlo, Stefan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008641/
https://ncbi.nlm.nih.gov/pubmed/24491980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmed.2014.01.004
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