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Glatiramer Acetate (Copaxone) Modulates Platelet Activation and Inhibits Thrombin-Induced Calcium Influx: Possible Role of Copaxone in Targeting Platelets during Autoimmune Neuroinflammation

BACKGROUND: Glatiramer acetate (GA, Copaxone, Copolymer-1) is an FDA approved drug for the treatment of MS and it is very effective in suppressing neuroinflammation in experimental autoimmune encephalitis (EAE), an animal model of MS. Although this drug was designed to inhibit pathogenic T cells, th...

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Main Authors: Starossom, Sarah C., Veremeyko, Tatyana, Dukhinova, Marina, Yung, Amanda W. Y., Ponomarev, Eugene D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008572/
https://ncbi.nlm.nih.gov/pubmed/24788965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096256
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