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Glatiramer Acetate (Copaxone) Modulates Platelet Activation and Inhibits Thrombin-Induced Calcium Influx: Possible Role of Copaxone in Targeting Platelets during Autoimmune Neuroinflammation

BACKGROUND: Glatiramer acetate (GA, Copaxone, Copolymer-1) is an FDA approved drug for the treatment of MS and it is very effective in suppressing neuroinflammation in experimental autoimmune encephalitis (EAE), an animal model of MS. Although this drug was designed to inhibit pathogenic T cells, th...

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Bibliografiske detaljer
Main Authors: Starossom, Sarah C., Veremeyko, Tatyana, Dukhinova, Marina, Yung, Amanda W. Y., Ponomarev, Eugene D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008572/
https://ncbi.nlm.nih.gov/pubmed/24788965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096256
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