Glatiramer Acetate (Copaxone) Modulates Platelet Activation and Inhibits Thrombin-Induced Calcium Influx: Possible Role of Copaxone in Targeting Platelets during Autoimmune Neuroinflammation

BACKGROUND: Glatiramer acetate (GA, Copaxone, Copolymer-1) is an FDA approved drug for the treatment of MS and it is very effective in suppressing neuroinflammation in experimental autoimmune encephalitis (EAE), an animal model of MS. Although this drug was designed to inhibit pathogenic T cells, th...

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Hlavní autoři: Starossom, Sarah C., Veremeyko, Tatyana, Dukhinova, Marina, Yung, Amanda W. Y., Ponomarev, Eugene D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008572/
https://ncbi.nlm.nih.gov/pubmed/24788965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096256
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