Cyclic AMP Pathway Suppress Autoimmune Neuroinflammation by Inhibiting Functions of Encephalitogenic CD4 T Cells and Enhancing M2 Macrophage Polarization at the Site of Inflammation

Although it has been demonstrated that cAMP pathway affect both adaptive and innate cell functions, the role of this pathway in the regulation of T-cell-mediated central nervous system (CNS) autoimmune inflammation, such as in experimental autoimmune encephalomyelitis (EAE), remains unclear. It is a...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Veremeyko, Tatyana, Yung, Amanda W. Y., Dukhinova, Marina, Kuznetsova, Inna S., Pomytkin, Igor, Lyundup, Alexey, Strekalova, Tatyana, Barteneva, Natasha S., Ponomarev, Eugene D.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788911/
https://ncbi.nlm.nih.gov/pubmed/29422898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00050
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