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Mechanisms of m-cresol induced protein aggregation studied using a model protein cytochrome c()
Multi-dose protein formulations require an effective antimicrobial preservative (AP) to inhibit microbial growth during long-term storage of unused formulations. m-cresol is one such AP, but has been shown to cause protein aggregation. However, the fundamental physical mechanisms underlying such AP-...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4008150/ https://ncbi.nlm.nih.gov/pubmed/21229618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.22426 |
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