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ROLE OF BENZYL ALCOHOL IN THE UNFOLDING AND AGGREGATION OF INTERFERON α-2A(†)

Benzyl alcohol (BA) is the most widely used antimicrobial preservative in multi-dose protein formulations, and has been shown to cause protein aggregation. Our previous work on a model protein cytochrome c demonstrated that this phenomenon occurs via partial unfolding. Here, we examine the validity...

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Detalles Bibliográficos
Publicado en:J Pharm Sci
Main Authors: Bis, Regina L., Singh, Surinder M., Cabello-Villegas, Javier, Mallela, Krishna M.G.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312256/
https://ncbi.nlm.nih.gov/pubmed/25100180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.24105
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