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ROLE OF BENZYL ALCOHOL IN THE UNFOLDING AND AGGREGATION OF INTERFERON α-2A(†)
Benzyl alcohol (BA) is the most widely used antimicrobial preservative in multi-dose protein formulations, and has been shown to cause protein aggregation. Our previous work on a model protein cytochrome c demonstrated that this phenomenon occurs via partial unfolding. Here, we examine the validity...
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| Publicado no: | J Pharm Sci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4312256/ https://ncbi.nlm.nih.gov/pubmed/25100180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.24105 |
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