Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

[Image: see text] During the course of our research efforts to develop a potent and selective γ-secretase inhibitor for the treatment of Alzheimer's disease, we investigated a series of carboxamide-substituted sulfonamides. Optimization based on potency, Notch/amyloid-β precursor protein select...

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Autors principals: Gillman, Kevin W., Starrett, John E., Parker, Michael F., Xie, Kai, Bronson, Joanne J., Marcin, Lawrence R., McElhone, Kate E., Bergstrom, Carl P., Mate, Robert A., Williams, Richard, Meredith, Jere E., Burton, Catherine R., Barten, Donna M., Toyn, Jeremy H., Roberts, Susan B., Lentz, Kimberley A., Houston, John G., Zaczek, Robert, Albright, Charles F., Decicco, Carl P., Macor, John E., Olson, Richard E.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2010
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007960/
https://ncbi.nlm.nih.gov/pubmed/24900185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1000239
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