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Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery
[Image: see text] Fragment screening of phosphoinositide-dependent kinase-1 (PDK1) in a biochemical kinase assay afforded hits that were characterized and prioritized based on ligand efficiency and binding interactions with PDK1 as determined by NMR. Subsequent crystallography and follow-up screenin...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical Society
2010
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4007849/ https://ncbi.nlm.nih.gov/pubmed/24900229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100136n |
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