Optimization of an Albumin-Binding Prodrug of Doxorubicin That Is Cleaved by Prostate-Specific Antigen

[Image: see text] We have developed a novel albumin-binding prodrug of doxorubicin that incorporates p-aminobenzyloxycarbonyl (PABC) as a 1,6 self-immolative spacer in addition to the heptapeptide, Arg-Ser-Ser-Tyr-Tyr-Ser-Leu, as a substrate for the prostate-specific antigen (PSA) that is overexpres...

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Detaylı Bibliyografya
Asıl Yazarlar: Elsadek, Bakheet, Graeser, Ralph, Warnecke, André, Unger, Clemens, Saleem, Tahia, El-Melegy, Nagla, Madkor, Hafez, Kratz, Felix
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2010
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007830/
https://ncbi.nlm.nih.gov/pubmed/24900200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100060m
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