Discovery of Omecamtiv Mecarbil the First, Selective, Small Molecule Activator of Cardiac Myosin

[Image: see text] We report the design, synthesis, and optimization of the first, selective activators of cardiac myosin. Starting with a poorly soluble, nitro-aromatic hit compound (1), potent, selective, and soluble myosin activators were designed culminating in the discovery of omecamtiv mecarbil...

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Huvudupphovsmän: Morgan, Bradley P., Muci, Alexander, Lu, Pu-Ping, Qian, Xiangping, Tochimoto, Todd, Smith, Whitney W., Garard, Marc, Kraynack, Erica, Collibee, Scott, Suehiro, Ion, Tomasi, Adam, Valdez, S. Corey, Wang, Wenyue, Jiang, Hong, Hartman, James, Rodriguez, Hector M., Kawas, Raja, Sylvester, Sheila, Elias, Kathleen A., Godinez, Guillermo, Lee, Kenneth, Anderson, Robert, Sueoka, Sandra, Xu, Donghong, Wang, Zhengping, Djordjevic, Nebojsa, Malik, Fady I., Morgans, David J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2010
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007828/
https://ncbi.nlm.nih.gov/pubmed/24900233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100138q
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