Discovery of Omecamtiv Mecarbil the First, Selective, Small Molecule Activator of Cardiac Myosin

[Image: see text] We report the design, synthesis, and optimization of the first, selective activators of cardiac myosin. Starting with a poorly soluble, nitro-aromatic hit compound (1), potent, selective, and soluble myosin activators were designed culminating in the discovery of omecamtiv mecarbil...

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Xehetasun bibliografikoak
Egile Nagusiak: Morgan, Bradley P., Muci, Alexander, Lu, Pu-Ping, Qian, Xiangping, Tochimoto, Todd, Smith, Whitney W., Garard, Marc, Kraynack, Erica, Collibee, Scott, Suehiro, Ion, Tomasi, Adam, Valdez, S. Corey, Wang, Wenyue, Jiang, Hong, Hartman, James, Rodriguez, Hector M., Kawas, Raja, Sylvester, Sheila, Elias, Kathleen A., Godinez, Guillermo, Lee, Kenneth, Anderson, Robert, Sueoka, Sandra, Xu, Donghong, Wang, Zhengping, Djordjevic, Nebojsa, Malik, Fady I., Morgans, David J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2010
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007828/
https://ncbi.nlm.nih.gov/pubmed/24900233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100138q
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