RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland

RUNX2, a master regulator of osteogenesis, is oncogenic in the lymphoid lineage; however, little is known about its role in epithelial cancers. Upregulation of RUNX2 in cell lines correlates with increased invasiveness and the capacity to form osteolytic disease in models of breast and prostate canc...

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Main Authors: McDonald, Laura, Ferrari, Nicola, Terry, Anne, Bell, Margaret, Mohammed, Zahra M., Orange, Clare, Jenkins, Alma, Muller, William J., Gusterson, Barry A., Neil, James C., Edwards, Joanne, Morris, Joanna S., Cameron, Ewan R., Blyth, Karen
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Limited 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007404/
https://ncbi.nlm.nih.gov/pubmed/24626992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.015040
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