RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland

RUNX2, a master regulator of osteogenesis, is oncogenic in the lymphoid lineage; however, little is known about its role in epithelial cancers. Upregulation of RUNX2 in cell lines correlates with increased invasiveness and the capacity to form osteolytic disease in models of breast and prostate canc...

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Autors principals: McDonald, Laura, Ferrari, Nicola, Terry, Anne, Bell, Margaret, Mohammed, Zahra M., Orange, Clare, Jenkins, Alma, Muller, William J., Gusterson, Barry A., Neil, James C., Edwards, Joanne, Morris, Joanna S., Cameron, Ewan R., Blyth, Karen
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Limited 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007404/
https://ncbi.nlm.nih.gov/pubmed/24626992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.015040
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