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Prolactin cooperates with loss of p53 to promote claudin low mammary carcinomas

TP53 is one of the most commonly mutated genes in cancer. In breast cancer, it is mutated in about 40% of primary clinical tumors and is associated with poor survival. The mammotrophic hormone, prolactin (PRL), and/or its receptor are also expressed in many breast cancers, and accumulating epidemiol...

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Hlavní autoři: O’Leary, Kathleen A., Rugowski, Debra E., Sullivan, Ruth, Schuler, Linda A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007359/
https://ncbi.nlm.nih.gov/pubmed/23873024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.278
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