Prolactin Activates ERα in the Absence of Ligand in Female Mammary Development and Carcinogenesis in Vivo

Resistance of estrogen receptor positive (ERα+) breast cancers to antiestrogens is a major factor in the mortality of this disease. Although activation of ERα in the absence of ligand is hypothesized to contribute to this resistance, the potency of this mechanism in vivo is not clear. Epidemiologic...

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Detalhes bibliográficos
Main Authors: O'Leary, Kathleen A., Jallow, Fatou, Rugowski, Debra E., Sullivan, Ruth, Sinkevicius, Kerstin W., Greene, Geoffrey L., Schuler, Linda A.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Cancer-Oncogenes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836081/
https://ncbi.nlm.nih.gov/pubmed/24064365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1533
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