Prolactin Activates ERα in the Absence of Ligand in Female Mammary Development and Carcinogenesis in Vivo

Resistance of estrogen receptor positive (ERα+) breast cancers to antiestrogens is a major factor in the mortality of this disease. Although activation of ERα in the absence of ligand is hypothesized to contribute to this resistance, the potency of this mechanism in vivo is not clear. Epidemiologic...

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Main Authors: O'Leary, Kathleen A., Jallow, Fatou, Rugowski, Debra E., Sullivan, Ruth, Sinkevicius, Kerstin W., Greene, Geoffrey L., Schuler, Linda A.
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2013
Fag:
Cancer-Oncogenes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836081/
https://ncbi.nlm.nih.gov/pubmed/24064365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1533
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